Atletico Paranaense beat America de Cali 0-1. The winner had to work for it: 1 from 12 shots. Best on the pitch was H. Quiñónes, rated 7.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   COL 4-4-2·3-4-2-1 BRA
   Coach: J. Osorio · António OliveiraReferee: J. Argote📍 Estadio Hernán Ramírez Villegas
2. 1. First half
   2. 9'
      BRA
      Yellow card
      Léo Cittadini
   3. 13'
      COL
      Yellow card
      R. Urena
3. 1. Second half
   2. 46'
      BRA
      Yellow card
      Zé Ivaldo
   3. 46'
      BRA
      Substitution
      ▲Marcinho▼Khellven
   4. 50'
      BRA
      VAR review
      Vitinho
   5. 57'
      BRA
      Yellow card
      Marcinho
   6. 58'
      COL
      Substitution
      ▲J. Rodríguez▼C. Cortés
   7. 65'
      BRA
      Substitution
      ▲Matheus Babi▼D. Terans
   8. 68'
      COL
      Substitution
      ▲E. Batalla▼L. Paz
   9. 70'
      BRA
      VAR review
      Bento
   10. 73'
       BRA
       GOOOAL!NikãoPenalty
   11. 84'
       BRA
       Substitution
       ▲Carlos Eduardo▼Vitinho
   12. 90+3'
       BRA
       Substitution
       ▲Erick▼Léo Cittadini