Santos beat Independiente 1-0. The winner had to work for it: 1 from 18 shots. Best on the pitch was João Paulo, rated 8.0.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   BRA 4-2-3-1·4-2-3-1 ARG
   Coach: Fernando Diniz · J. FalcioniReferee: W. Roldán📍 Estádio Urbano Caldeira
2. 1. First half
   2. 39'
      ARG
      Yellow card
      L. Rodriguez
3. 1. Second half
   2. 61'
      BRA
      Substitution
      ▲Lucas Braga▼Jean Mota
   3. 61'
      BRA
      Substitution
      ▲Carlos Sánchez▼Gabriel Pirani
   4. 66'
      BRA
      Yellow card
      Kaiky
   5. 69'
      BRA
      GOOOAL!Kaio Jorge
   6. 77'
      ARG
      Substitution
      ▲L. Gonzalez▼D. Blanco
   7. 77'
      ARG
      Substitution
      ▲B. Martinez▼S. Palacios
   8. 80'
      ARG
      Yellow card
      Juan M. Insaurralde
   9. 82'
      ARG
      Substitution
      ▲J. Herrera▼A. Velasco
   10. 83'
       BRA
       Substitution
       ▲Madson▼Kaio Jorge
   11. 83'
       BRA
       Substitution
       ▲Vinicius Zanocelo▼Pará
   12. 85'
       ARG
       Yellow card
       L. Gonzalez
   13. 90'
       BRA
       Yellow card
       Carlos Sánchez