Penarol beat Club Nacional 1-2. The winner had to work for it: 2 from 17 shots. Best on the pitch was Walter Gargano, rated 8.0.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   URU 4-5-1·4-2-3-1 URU
   Coach: A. Capuccio · M. LarrieraReferee: N. Pitana📍 Estadio Gran Parque Central
2. 1. First half
   2. 45+2'
      URU
      GOOOAL!A. CanobbioAssist: Agustín Álvarez Martínez
3. 1. Second half
   2. 46'
      URU
      Substitution
      ▲F. Carballo▼J. Trasante
   3. 46'
      URU
      Substitution
      ▲M. Cantera▼G. Neves
   4. 54'
      URU
      Substitution
      ▲A. D'Alessandro▼C. Cándido
   5. 65'
      URU
      Yellow card
      N. Marichal
   6. 65'
      URU
      Substitution
      ▲Maxi Pereira▼A. Canobbio
   7. 72'
      URU
      Substitution
      ▲A. Mendez▼N. Marichal
   8. 76'
      URU
      Yellow card
      A. Mendez
   9. 81'
      URU
      Substitution
      ▲A. Nahuelpán▼Agustín Álvarez Martínez
   10. 87'
       URU
       Substitution
       ▲Damian Musto▼Walter Gargano
   11. 87'
       URU
       Substitution
       ▲Valentín Rodríguez▼F. Torres
   12. 90'
       URU
       Yellow card
       Valentín Rodríguez
   13. 90+2'
       URU
       GOOOAL!Valentín RodríguezAssist: J. Trindade
   14. 90+5'
       URU
       GOOOAL!Gonzalo BergessioAssist: F. Carballo