Santos beat Libertad Asuncion 2-1. Santos played with ten from minute 57. Best on the pitch was Lucas Braga, rated 7.6.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   BRA 4-2-3-1·4-5-1 PAR
   Coach: Fernando Diniz · D. GarneroReferee: L. González📍 Estádio Urbano Caldeira
2. 1. First half
   2. 40'
      BRA
      VAR review
      Lucas Braga
   3. 40'
      PAR
      VAR review
      Lucas Braga
   4. 43'
      BRA
      GOOOAL!Carlos SánchezPenalty
   5. 45'
      PAR
      Yellow card
      Héctor Villalba
3. 1. Second half
   2. 51'
      BRA
      Yellow card
      Felipe Jonatan
   3. 57'
      BRA
      Red card
      Kaiky
   4. 59'
      BRA
      Substitution
      ▲Wagner▼Gabriel Pirani
   5. 59'
      PAR
      GOOOAL!Daniel Bocanegra
   6. 65'
      BRA
      Yellow card
      Wagner
   7. 70'
      PAR
      Substitution
      ▲Óscar Cardozo▼R. Martínez
   8. 70'
      PAR
      Substitution
      ▲Ivan Franco▼Héctor Villalba
   9. 76'
      PAR
      Substitution
      ▲I. Ramirez▼Camilo Mayada
   10. 77'
       PAR
       Substitution
       ▲Julio César Enciso▼S. Ferreira
   11. 82'
       PAR
       Yellow card
       Leonel Vangioni
   12. 88'
       PAR
       Substitution
       ▲B. Merlini▼Leonel Vangioni
   13. 89'
       BRA
       Substitution
       ▲Ivonei▼Jean Mota
   14. 90'
       BRA
       Substitution
       ▲Raniel▼Carlos Sánchez
   15. 90+3'
       PAR
       Own goalAlex Terra