Atletico Paranaense beat Penarol 1-2. Penarol controlled the ball — 60% possession — but had nothing to show for it. Best on the pitch was Agustín Álvarez Martínez, rated 7.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   URU 4-1-4-1·— BRA
   Coach: M. Larriera · —Referee: D. Haro📍 Estadio Campeón del Siglo
2. 1. First half
   2. -5'
      URU
      Yellow card
      Ezequiel Busquets
   3. 2'
      BRA
      GOOOAL!D. TeransAssist: Bissoli
   4. 13'
      BRA
      Yellow card
      Erick
   5. 22'
      URU
      GOOOAL!Agustín Álvarez MartínezAssist: F. Torres
   6. 33'
      BRA
      Yellow card
      Richard
   7. 40'
      URU
      Yellow card
      Jesús Trindade
3. 1. Second half
   2. 46'
      URU
      Substitution
      ▲Valentín Rodríguez▼J. Ramos
   3. 57'
      BRA
      Substitution
      ▲Léo Cittadini▼Richard
   4. 61'
      URU
      Substitution
      ▲Damian Musto▼Jesús Trindade
   5. 63'
      BRA
      Substitution
      ▲Pedro Rocha▼D. Terans
   6. 64'
      BRA
      Substitution
      ▲Nicolas▼Abner Vinicius
   7. 69'
      URU
      Substitution
      ▲Nicolás Gaitán▼Walter Gargano
   8. 75'
      BRA
      GOOOAL!Pedro Rocha
   9. 77'
      BRA
      Yellow card
      Nicolas
   10. 81'
       BRA
       Substitution
       ▲Renato Kayser▼Guilherme Bissoli
   11. 81'
       BRA
       Substitution
       ▲Christian▼Marcinho
   12. 83'
       BRA
       Yellow card
       Nikão
   13. 84'
       URU
       Yellow card
       Agustín Álvarez Martínez
   14. 84'
       URU
       Substitution
       ▲I. Laquintana▼A. Canobbio
   15. 84'
       URU
       Substitution
       ▲A. Nahuelpán▼Pablo Ceppelini
   16. 90'
       URU
       Yellow card
       Valentín Rodríguez
   17. 90'
       BRA
       Yellow card
       Léo Cittadini