Independiente Medellin beat America de Cali 2-1. The winner had to work for it: 2 from 24 shots. Best on the pitch was Vladimir Hernández, rated 8.0.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2022
   COL 4-2-3-1·3-5-1-1 COL
   Coach: J. Comesaña · J. OsorioReferee: Flavio Rodrigues De Souza📍 Estadio Atanasio Girardot
2. 1. First half
   2. 45+2'
      COL
      GOOOAL!Vladimir Hernández
3. 1. Second half
   2. 46'
      COL
      Substitution
      ▲J. Portilla▼L. Paz
   3. 46'
      COL
      Substitution
      ▲J. Micolta▼E. Moreno
   4. 48'
      COL
      GOOOAL!Adrian RamosAssist: J. Micolta
   5. 57'
      COL
      GOOOAL!Andres Cadavid
   6. 62'
      COL
      Substitution
      ▲D. Pino▼Iago Falqué
   7. 63'
      COL
      Substitution
      ▲A. Quintana▼Adrian Ramos
   8. 75'
      COL
      Substitution
      ▲J. Méndez▼A. Arregui
   9. 83'
      COL
      Substitution
      ▲D. Cambindo▼L. Pons
   10. 90+1'
       COL
       Substitution
       ▲J. Hernández▼Vladimir Hernández