Wanderers beat Cerro Largo 2-1. The winner had to work for it: 2 from 12 shots. Best on the pitch was K. Rolón, rated 7.5.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2022
   URU 4-2-3-1·4-4-2 URU
   Coach: D. Carreño · L. NúñezReferee: Á. Arteaga📍 Parque Alfredo Víctor Viera
2. 1. First half
   2. 30'
      URU
      Yellow card
      Adolfo Lima
   3. 35'
      URU
      Yellow card
      E. García
3. 1. Second half
   2. 51'
      URU
      GOOOAL!Leandro OnettoAssist: E. Villar
   3. 52'
      URU
      Yellow card
      H. Rivero
   4. 59'
      URU
      Substitution
      ▲D. Riolfo▼C. Bravo
   5. 67'
      URU
      Yellow card
      A. Max
   6. 68'
      URU
      Yellow card
      J. Aguirre
   7. 69'
      URU
      Yellow card
      L. Casiani
   8. 73'
      URU
      Substitution
      ▲M. Mendez▼M. Estol
   9. 73'
      URU
      Substitution
      ▲A. Santurio▼J. Acosta
   10. 74'
       URU
       GOOOAL!H. RiveroAssist: N. Quagliata
   11. 76'
       URU
       Yellow card
       Emiliano Villar
   12. 79'
       URU
       Substitution
       ▲Jorge Benguché▼Leandro Onetto
   13. 79'
       URU
       GOOOAL!D. RiolfoAssist: M. Méndez
   14. 82'
       URU
       Substitution
       ▲Santiago Martinez▼M. Enrique
   15. 85'
       URU
       Substitution
       ▲G. Wagner▼N. Quagliata
   16. 88'
       URU
       Substitution
       ▲N. Silva▼Adolfo Lima
   17. 89'
       URU
       Substitution
       ▲Jonathan Ramis▼Emiliano Villar
   18. 89'
       URU
       Substitution
       ▲G. Machado▼L. Casiani