FBC Melgar beat Cienciano 1-0. The winner had to work for it: 1 from 20 shots. Best on the pitch was Bernardo Cuesta, rated 7.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2022
   PER 4-3-3·4-2-3-1 PER
   Coach: N. Lorenzo · G. AmeliReferee: A. Rojas📍 Estadio de la Universidad Nacional San Agustín
2. 1. First half
   2. 14'
      PER
      Yellow card
      N. Rinaldi
   3. 16'
      PER
      Yellow card
      Angel Romero
   4. 19'
      PER
      GOOOAL!Bernardo Cuesta
   5. 45'
      PER
      Yellow card
      J. Estrada
3. 1. Second half
   2. 46'
      PER
      Substitution
      ▲Fernando Guerrero▼N. Rinaldi
   3. 46'
      PER
      Substitution
      ▲A. Quintana▼Alexis Cossio
   4. 57'
      PER
      Yellow card
      H. Orzán
   5. 61'
      PER
      Yellow card
      A. Ramos
   6. 65'
      PER
      Substitution
      ▲W. Tandazo▼M. Pérez Guedes
   7. 68'
      PER
      Substitution
      ▲F. Curuchet▼Carlos Beltran
   8. 79'
      PER
      Yellow card
      Paolo Fuentes
   9. 80'
      PER
      Substitution
      ▲K. Quevedo▼C. Bordacahar
   10. 81'
       PER
       Substitution
       ▲J. Archimbaud▼A. Arias
   11. 83'
       PER
       Substitution
       ▲M. Carpio▼Adrián Ugarriza
   12. 85'
       PER
       Yellow card
       J. Archimbaud
   13. 90+4'
       PER
       Substitution
       ▲Johnny Vidales▼Bernardo Cuesta