Guairena FC and Independiente Medellin drew 3-3. Independiente Medellin controlled the ball — 65% possession — but had nothing to show for it. Best on the pitch was L. Pons, rated 8.6.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2022
   PAR 4-3-3·4-1-4-1 COL
   Coach: T. Duarte · J. ComesañaReferee: A. Menéndez📍 Estadio Defensores del Chaco
2. 1. First half
   2. 6'
      PAR
      GOOOAL!M. OtazúAssist: P. Ayala
   3. 30'
      PAR
      Yellow card
      J. Santacruz
   4. 33'
      COL
      GOOOAL!L. Pons
   5. 37'
      COL
      Substitution
      ▲Felipe Pardo▼Victor Moreno
   6. 38'
      COL
      GOOOAL!A. ArreguiAssist: L. Pons
3. 1. Second half
   2. 46'
      PAR
      Substitution
      ▲Cesar Villagra▼Y. Murillo
   3. 46'
      PAR
      Substitution
      ▲D. Godoy▼Rosalino Toledo
   4. 52'
      PAR
      Yellow card
      Richard Salinas
   5. 56'
      PAR
      GOOOAL!Pablo AyalaAssist: R. Salinas
   6. 63'
      COL
      Substitution
      ▲Yulián Gómez▼Germán Gutiérrez
   7. 65'
      COL
      Own goalJuan Guillermo Arboleda
   8. 66'
      PAR
      Yellow card
      Juan Aguilar
   9. 79'
      COL
      Yellow card
      J. Méndez
   10. 80'
       COL
       Substitution
       ▲Vladimir Hernández▼D. Loaiza
   11. 80'
       COL
       Substitution
       ▲J. Cuesta▼J. Pineda
   12. 87'
       PAR
       Substitution
       ▲A. Cáceres▼M. Otazú
   13. 87'
       PAR
       Substitution
       ▲David Mendoza▼Pablo Ayala
   14. 90+1'
       COL
       GOOOAL!J. CuestaAssist: L. Pons
   15. 90+2'
       PAR
       Substitution
       ▲M. Acosta▼Richard Salinas