Independiente beat General Caballero 2-0. The winner had to work for it: 2 from 16 shots. Best on the pitch was A. Soñora, rated 7.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2022
   ARG 4-3-3·4-2-3-1 PAR
   Coach: E. Domínguez · G. BobadillaReferee: G. Guerrero📍 Estadio Libertadores de América
2. 1. First half
   2. 28'
      PAR
      Substitution
      ▲E. Duarte▼M. Mareco
   3. 29'
      ARG
      Yellow card
      S. Barreto
   4. 33'
      ARG
      Yellow card
      Damián Batallini
   5. 35'
      PAR
      Yellow card
      J. Vera
3. 1. Second half
   2. 46'
      ARG
      Substitution
      ▲A. Soñora▼G. Togni
   3. 46'
      ARG
      Substitution
      ▲J. Laso▼S. Barreto
   4. 46'
      ARG
      Substitution
      ▲T. A. Pozzo▼Damián Batallini
   5. 58'
      PAR
      Substitution
      ▲J. Marabel▼L. Fernández
   6. 64'
      ARG
      Substitution
      ▲R. L. Marquez De Meneses▼G. Asis
   7. 66'
      ARG
      GOOOAL!L. Benegas
   8. 67'
      PAR
      Substitution
      ▲S. Bustos▼T. Lezcano
   9. 67'
      PAR
      Substitution
      ▲W. Rodríguez▼Guillermo Hauche
   10. 67'
       PAR
       Substitution
       ▲C. González▼Santiago Salcedo
   11. 73'
       ARG
       GOOOAL!A. SoñoraAssist: R. Márquez
   12. 75'
       ARG
       Substitution
       ▲C. Benavídez▼D. Blanco