Independiente Medellin beat 9 de Octubre 2-1. The winner had to work for it: 2 from 20 shots. Best on the pitch was D. Luna, rated 8.3.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2022
   COL 4-2-3-1·4-2-3-1 ECU
   Coach: J. Comesaña · J. LeónReferee: Y. Herrera📍 Estadio Atanasio Girardot
2. 1. First half
   2. 5'
      ECU
      GOOOAL!M. LucasAssist: D. Luna
   3. 9'
      COL
      GOOOAL!Vladimir Hernández
   4. 10'
      COL
      Yellow card
      A. Arregui
   5. 37'
      COL
      Substitution
      ▲B. Castrillón▼Felipe Pardo
   6. 42'
      ECU
      Yellow card
      K. Becerra
   7. 44'
      ECU
      Yellow card
      J. Pinos
3. 1. Second half
   2. 53'
      COL
      Yellow card
      D. Loaiza
   3. 55'
      COL
      Substitution
      ▲Andres Ricaurte▼D. Loaiza
   4. 56'
      COL
      Yellow card
      L. Pons
   5. 67'
      ECU
      Yellow card
      Ricardo Phillips
   6. 71'
      ECU
      Substitution
      ▲A. Stephens▼Ricardo Phillips
   7. 83'
      ECU
      Yellow card
      Geovanny Nazareno
   8. 85'
      COL
      Yellow card
      Andres Ricaurte
   9. 87'
      COL
      Substitution
      ▲J. Cuesta▼Vladimir Hernández
   10. 90+2'
       ECU
       Yellow card
       D. Luna
   11. 90+3'
       ECU
       Substitution
       ▲W. Caicedo▼D. Luna
   12. 90+3'
       ECU
       Substitution
       ▲Glendys Mina▼N. Williams
   13. 90+3'
       ECU
       Substitution
       ▲É. Cetre▼Jose Cazares
   14. 90+4'
       COL
       GOOOAL!B. CastrillónAssist: A. Ricaurte
   15. 90+6'
       COL
       Yellow card
       B. Castrillón