Independiente beat Deportivo La Guaira 0-2. The winner had to work for it: 2 from 15 shots. Best on the pitch was D. Blanco, rated 8.2.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2022
   VEN 3-4-2-1·4-5-1 ARG
   Coach: D. Farías · E. DomínguezReferee: N. Gallo📍 Estadio Olímpico de la UCV
2. 1. First half
   2. 17'
      ARG
      Yellow card
      S. Barreto
   3. 22'
      VEN
      Yellow card
      F. La Mantia
   4. 26'
      ARG
      Yellow card
      G. Asis
3. 1. Second half
   2. 59'
      VEN
      Substitution
      ▲Y. Rivas▼D. Paz
   3. 66'
      VEN
      Yellow card
      Y. Rivas
   4. 67'
      ARG
      GOOOAL!D. Blanco
   5. 70'
      VEN
      Substitution
      ▲H. García▼S. Herrera
   6. 75'
      VEN
      Yellow card
      A. Flores
   7. 79'
      ARG
      Substitution
      ▲Leandro Fernandez▼G. Togni
   8. 79'
      ARG
      Substitution
      ▲C. Benavídez▼G. Asis
   9. 84'
      VEN
      Substitution
      ▲S. Unrein▼Jovanny Bolívar
   10. 84'
       VEN
       Substitution
       ▲L. Mosquera▼L. Ovalle
   11. 86'
       ARG
       Yellow card
       L. Romero
   12. 90'
       ARG
       GOOOAL!Leandro Fernandez
   13. 90+2'
       ARG
       Substitution
       ▲R. L. Marquez De Meneses▼T. A. Pozzo
   14. 90+5'
       VEN
       Yellow card
       J. Aramburu