Lanús beat Wanderers 0-1. The winner had to work for it: 1 from 12 shots. Best on the pitch was N. Quagliata, rated 8.2.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2022
   URU 4-4-2·4-4-2 ARG
   Coach: D. Carreño · J. AlmirónReferee: Wilton Pereira Sampaio📍 Estadio Centenario
2. 1. First half
   2. 45'
      ARG
      Yellow card
      M. Gonzalez
3. 1. Second half
   2. 46'
      ARG
      Substitution
      ▲Á. Gonzalez▼M. Gonzalez
   3. 49'
      ARG
      Yellow card
      Lautaro Acosta
   4. 53'
      URU
      Substitution
      ▲H. Rivero▼N. Ferreira
   5. 53'
      URU
      Substitution
      ▲D. Hernández▼E. Tellechea
   6. 79'
      ARG
      GOOOAL!José SandAssist: Á. Gonzalez
   7. 80'
      URU
      Substitution
      ▲E. Vidart▼G. Wagner
   8. 81'
      ARG
      Yellow card
      Nicolas Pasquini
   9. 86'
      URU
      Substitution
      ▲A. Santurio▼N. Quagliata
   10. 87'
       ARG
       Substitution
       ▲Y. Cabral▼José Sand
   11. 90+4'
       URU
       Yellow card
       J. Aguirre