Independiente beat General Caballero 0-4. Best on the pitch was Leandro Fernandez, rated 8.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2022
   PAR 4-4-2·4-1-3-2 ARG
   Coach: L. Theiler · E. DomínguezReferee: N. Gamboa📍 Estadio Defensores del Chaco
2. 1. First half
   2. 28'
      ARG
      Yellow card
      L. Romero
   3. 41'
      PAR
      Yellow card
      Santiago Salcedo
   4. 42'
      ARG
      GOOOAL!D. BlancoPenalty
   5. 45+1'
      ARG
      Yellow card
      Damián Batallini
3. 1. Second half
   2. 46'
      PAR
      Substitution
      ▲Leandro Corulo▼J. Barreto
   3. 46'
      PAR
      Substitution
      ▲D. Martínez▼C. Ayala
   4. 58'
      ARG
      GOOOAL!T. A. PozzoAssist: D. Batallini
   5. 60'
      PAR
      Substitution
      ▲H. Lezcano▼R. Ortiz
   6. 67'
      PAR
      Substitution
      ▲S. Bustos▼K. Fernández
   7. 67'
      ARG
      Substitution
      ▲Leandro Fernandez▼Damián Batallini
   8. 67'
      ARG
      Substitution
      ▲Andrés Roa▼T. A. Pozzo
   9. 71'
      PAR
      Yellow card
      Leandro Corulo
   10. 73'
       PAR
       Substitution
       ▲C. Gavilán▼M. Escobar
   11. 75'
       ARG
       Substitution
       ▲J. Cazares▼J. Romero
   12. 86'
       ARG
       Substitution
       ▲G. Togni▼D. Blanco
   13. 87'
       ARG
       GOOOAL!Leandro FernandezAssist: A. Vigo
   14. 90+4'
       ARG
       GOOOAL!A. SoñoraAssist: L. Fernández