LDU de Quito beat Antofagasta 1-2. The winner had to work for it: 2 from 18 shots. Antofagasta played with ten from minute 73. Best on the pitch was N. Angulo, rated 8.5.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2022
   CHI 4-4-2·4-2-3-1 ECU
   Coach: D. Reveco · É. MéndezReferee: M. Espinoza📍 Estadio Regional Calvo y Bascuñán
2. 1. First half
   2. -5'
      ECU
      Yellow card
      M. Corozo
   3. 12'
      ECU
      Yellow card
      Z. Romero
   4. 18'
      CHI
      GOOOAL!M. LópezAssist: J. Flores
   5. 37'
      ECU
      Yellow card
      A. Alvarado
3. 1. Second half
   2. 46'
      CHI
      Substitution
      ▲I. Ledezma▼A. Cuadra
   3. 52'
      ECU
      GOOOAL!N. AnguloAssist: T. Molina
   4. 58'
      ECU
      Substitution
      ▲A. López▼A. Alvarado
   5. 67'
      ECU
      GOOOAL!A. LópezAssist: N. Angulo
   6. 69'
      CHI
      Substitution
      ▲B. Hurtado▼C. Rodríguez
   7. 73'
      CHI
      Red card
      E. Ahumada
   8. 76'
      CHI
      Yellow card
      J. Flores
   9. 76'
      CHI
      Substitution
      ▲Cristián Rojas▼J. Flores
   10. 80'
       CHI
       Yellow card
       L. Vega
   11. 84'
       CHI
       Substitution
       ▲A. Souper▼Marco Collao Ramos
   12. 85'
       CHI
       Substitution
       ▲Gabriel Torres▼M. López
   13. 87'
       ECU
       Substitution
       ▲A. Muñoz▼N. Angulo
   14. 90'
       CHI
       Yellow card
       F. Bravo
   15. 90+1'
       ECU
       Yellow card
       Luis Caicedo
   16. 90+4'
       ECU
       Substitution
       ▲Jefferson Arce▼M. Hoyos
   17. 90+5'
       ECU
       Substitution
       ▲F. Guerra▼José Quintero