Internacional beat Independiente Medellin 2-0. The winner had to work for it: 2 from 20 shots. Edenílson scored 2 goals. Best on the pitch was Edenílson, rated 8.3.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2022
   BRA 4-4-2·3-4-3 COL
   Coach: Mano Menezes · J. ComesañaReferee: F. Tello📍 Estádio José Pinheiro Borda
2. 1. First half
   2. 19'
      BRA
      GOOOAL!Edenílson
   3. 20'
      BRA
      Yellow card
      Edenílson
   4. 40'
      COL
      Yellow card
      Juan Guillermo Arboleda
3. 1. Second half
   2. 46'
      COL
      Substitution
      ▲Felipe Pardo▼Yulián Gómez
   3. 57'
      BRA
      GOOOAL!Edenílson
   4. 66'
      BRA
      Substitution
      ▲Liziero▼C. de Pena
   5. 66'
      BRA
      Substitution
      ▲Alemão▼David da Fonseca
   6. 66'
      COL
      Substitution
      ▲B. Castrillón▼J. Díaz
   7. 66'
      COL
      Substitution
      ▲Andres Ricaurte▼Vladimir Hernández
   8. 71'
      BRA
      Substitution
      ▲Moisés▼Renê
   9. 71'
      BRA
      Substitution
      ▲Heitor▼Fabricio Bustos
   10. 81'
       BRA
       Substitution
       ▲Estevão▼Mauricio
   11. 83'
       COL
       Substitution
       ▲D. Cambindo▼L. Pons
   12. 83'
       COL
       Substitution
       ▲J. Cuesta▼J. Pineda