Sao Paulo beat Jorge Wilstermann 3-0. Rodrigo Nestor scored 2 goals. Best on the pitch was Rodrigo Nestor, rated 10.0.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2022
   BRA 3-4-2-1·5-3-2 BOL
   Coach: Rogério Ceni · S. MigliaccioReferee: Á. Arteaga📍 Estádio Cícero Pompeu de Toledo
2. 1. First half
   2. 6'
      BRA
      GOOOAL!Rodrigo NestorAssist: Eder
   3. 17'
      BRA
      GOOOAL!Rodrigo NestorAssist: Nikão
   4. 21'
      BOL
      Yellow card
      Edson Perez
   5. 28'
      BRA
      Yellow card
      Welington
3. 1. Second half
   2. 46'
      BRA
      Substitution
      ▲Reinaldo▼Welington
   3. 46'
      BOL
      Substitution
      ▲José Vargas▼C. Áñez
   4. 46'
      BOL
      Substitution
      ▲Maximiliano Ortíz▼Robson dos Santos
   5. 47'
      BRA
      GOOOAL!PatrickAssist: Rodrigo Nestor
   6. 60'
      BRA
      Substitution
      ▲Igor Vinicius▼Rafinha
   7. 60'
      BRA
      Substitution
      ▲Luciano▼Nikão
   8. 60'
      BRA
      Substitution
      ▲Thalles▼Rodrigo Nestor
   9. 70'
      BOL
      Substitution
      ▲M. Villarroel▼R. Castro
   10. 70'
       BOL
       Substitution
       ▲Luis Francisco Rodriguez Zegada▼Edson Perez
   11. 73'
       BRA
       Substitution
       ▲Luan▼G. Neves
   12. 79'
       BOL
       Substitution
       ▲Andrés Chávez▼Serginho