Independiente Medellin and Guairena FC drew 1-1. Independiente Medellin controlled the ball — 67% possession — but had nothing to show for it. Best on the pitch was Andres Ricaurte, rated 8.3.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2022
   COL 4-2-3-1·4-3-3 PAR
   Coach: J. Comesaña · T. DuarteReferee: D. Herrera📍 Estadio Hernán Ramírez Villegas
2. 1. First half
   2. 27'
      COL
      GOOOAL!D. CambindoAssist: F. Pardo
   3. 30'
      PAR
      Yellow card
      Joel Jiménez
   4. 32'
      PAR
      Yellow card
      A. Giménez
   5. 39'
      COL
      Yellow card
      Yulián Gómez
   6. 39'
      PAR
      Yellow card
      Richard Salinas
3. 1. Second half
   2. 46'
      PAR
      Substitution
      ▲C. Duarte▼J. Santacruz
   3. 46'
      PAR
      Substitution
      ▲L. Comas▼Richard Salinas
   4. 60'
      PAR
      GOOOAL!C. DuarteAssist: L. Comas
   5. 61'
      PAR
      Substitution
      ▲Rosalino Toledo▼Pablo Ayala
   6. 69'
      PAR
      Substitution
      ▲M. Maciel▼M. Otazú
   7. 78'
      COL
      Substitution
      ▲Vladimir Hernández▼Felipe Pardo
   8. 78'
      COL
      Substitution
      ▲J. Díaz▼A. Arregui
   9. 78'
      PAR
      Substitution
      ▲A. Cáceres▼D. Godoy
   10. 83'
       COL
       Yellow card
       J. Pineda
   11. 83'
       COL
       Substitution
       ▲B. Castrillón▼J. Mosquera
   12. 86'
       COL
       Substitution
       ▲Edwar López▼D. Cambindo