Sao Paulo beat Ayacucho FC 1-0. Best on the pitch was Thalles, rated 7.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2022
   BRA 3-4-2-1·5-4-1 PER
   Coach: Rogério Ceni · A. ApudReferee: C. Benitez📍 Estádio Cícero Pompeu de Toledo
2. 1. First half
   2. 19'
      PER
      Yellow card
      J. Toledo
   3. 35'
      PER
      Yellow card
      H. Magallanes
3. 1. Second half
   2. 46'
      BRA
      Substitution
      ▲Emiliano Rigoni▼Leo Almeida
   3. 46'
      BRA
      Substitution
      ▲Gabriel Maioli▼Luan
   4. 46'
      PER
      Substitution
      ▲C. Olascuaga▼C. Techera
   5. 55'
      BRA
      Substitution
      ▲Igor Vinicius▼Jonas Toró
   6. 72'
      BRA
      GOOOAL!Caio Matheus
   7. 74'
      BRA
      Substitution
      ▲Alisson▼Juan
   8. 78'
      PER
      Yellow card
      E. Páucar
   9. 80'
      PER
      Substitution
      ▲S. Gonzáles▼A. Romaní
   10. 80'
       PER
       Substitution
       ▲S. Rebagliati▼Erick Barrios
   11. 81'
       PER
       Substitution
       ▲J. Parodi▼E. Páucar
   12. 81'
       PER
       Substitution
       ▲Juan Morales▼N. Royón
   13. 82'
       BRA
       Substitution
       ▲Palmberg▼Thalles