Colo Colo beat Internacional 2-0. The winner had to work for it: 2 from 12 shots. Best on the pitch was G. Costa, rated 7.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2022
   CHI 4-2-3-1·4-2-3-1 BRA
   Coach: G. Quinteros · Mano MenezesReferee: P. Loustau📍 Estadio Monumental David Arellano
2. 1. First half
   2. 12'
      CHI
      GOOOAL!J. LuceroAssist: G. Costa
   3. 17'
      BRA
      Yellow card
      Gabriel
   4. 28'
      BRA
      Substitution
      ▲Moisés▼Renê
3. 1. Second half
   2. 46'
      BRA
      Substitution
      ▲Rodrigo Moledo▼Heitor
   3. 55'
      CHI
      GOOOAL!P. SolariAssist: G. Costa
   4. 62'
      BRA
      Substitution
      ▲David da Fonseca▼Gabriel
   5. 62'
      CHI
      Yellow card
      C. Fuentes
   6. 62'
      BRA
      Substitution
      ▲Mauricio▼Alan Patrick
   7. 70'
      CHI
      Yellow card
      J. Lucero
   8. 74'
      CHI
      Substitution
      ▲Vicente Pizarro▼C. Fuentes
   9. 77'
      BRA
      Substitution
      ▲Estevão▼Pedro Henrique
   10. 90'
       BRA
       VAR review
       Estevão
   11. 90+3'
       BRA
       Yellow card
       Mauricio
   12. 90+4'
       CHI
       Substitution
       ▲B. Gutiérrez▼P. Solari