FBC Melgar knocked Internacional out on penalties 3-1, after a 0-0 draw. Internacional played with ten from minute 74. Best on the pitch was C. Caceda, rated 9.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2022
   BRA 4-1-4-1·4-1-4-1 PER
   Coach: Mano Menezes · P. LavallénReferee: R. Tobar📍 Estádio José Pinheiro Borda
2. 1. Second half
   2. 46'
      PER
      Substitution
      ▲L. Iberico▼C. Bordacahar
   3. 55'
      PER
      Yellow card
      P. Reyna
   4. 59'
      PER
      Substitution
      ▲K. G. Cabrera Nakamura▼W. Tandazo
   5. 65'
      BRA
      Substitution
      ▲Taison▼Alan Patrick
   6. 74'
      BRA
      Red card
      Gabriel
   7. 79'
      BRA
      Substitution
      ▲Pedro Henrique▼Wanderson
   8. 80'
      BRA
      Substitution
      ▲Mikael▼B. Romero
   9. 82'
      PER
      Substitution
      ▲J. Archimbaud▼A. Arias
   10. 90+2'
       BRA
       Yellow card
       C. de Pena
3. 1. Penalties
   2. 120+1'
      BRA
      Shootout miss
      Edenílson
   3. 120+2'
      PER
      GOOOAL!K. G. Cabrera NakamuraPenalty shootout
   4. 120+3'
      BRA
      Shootout miss
      Taison
   5. 120+4'
      PER
      Shootout miss
      Leonel Galeano
   6. 120+5'
      BRA
      Shootout miss
      C. de Pena
   7. 120+6'
      PER
      GOOOAL!Bernardo CuestaPenalty shootout
   8. 120+7'
      BRA
      GOOOAL!Pedro HenriquePenalty shootout
   9. 120+8'
      PER
      GOOOAL!L. IbericoPenalty shootout