Defensa y Justicia beat Penarol 4-1. A. Sant'Anna scored 2 goals. Best on the pitch was A. Sant'Anna, rated 8.3.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2023
   ARG 4-2-3-1·3-4-3 URU
   Coach: J. Vaccari · A. AriasReferee: J. Argote📍 Estadio Norberto Tito Tomaghello
2. 1. First half
   2. 18'
      URU
      Substitution
      ▲K. Méndez▼B. Mansilla
   3. 24'
      URU
      Yellow card
      M. Arezo
   4. 24'
      ARG
      Substitution
      ▲Santiago Solari▼G. Alanis
   5. 26'
      ARG
      Yellow card
      K. Gutierrez
   6. 36'
      URU
      Yellow card
      K. Méndez
   7. 39'
      ARG
      GOOOAL!A. Sant'AnnaAssist: S. Solari
   8. 45+1'
      ARG
      GOOOAL!A. Sant'Anna
3. 1. Second half
   2. 46'
      URU
      Substitution
      ▲R. A. Saravia Salvia▼N. Herrera
   3. 58'
      URU
      GOOOAL!S. Rodríguez
   4. 64'
      ARG
      Substitution
      ▲L. T. Escalante▼D. Barbona
   5. 64'
      URU
      Substitution
      ▲Abel Hernández▼B. Betancor
   6. 70'
      ARG
      GOOOAL!N. FernandezAssist: A. Soto
   7. 74'
      URU
      Yellow card
      R. A. Saravia Salvia
   8. 80'
      ARG
      GOOOAL!G. Togni
   9. 81'
      ARG
      Yellow card
      G. Togni
   10. 82'
       URU
       Yellow card
       S. Rodríguez
   11. 83'
       ARG
       Yellow card
       A. Sant'Anna
   12. 84'
       URU
       Substitution
       ▲M. Alonso▼S. Rodríguez
   13. 84'
       URU
       Substitution
       ▲Lucas Hernández▼Valentín Rodríguez
   14. 89'
       ARG
       Substitution
       ▲Darío Cáceres▼G. Togni
   15. 89'
       ARG
       Substitution
       ▲J. Malatini▼K. Gutierrez