Cerro Largo knocked Danubio out on penalties 4-3, after a 2-2 draw. Danubio played with ten from minute 90. M. Affonso scored 2 goals. Best on the pitch was M. Affonso, rated 8.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2025
   Referee: Alexis Herrera, Venezuela📍 Estadio Arquitecto Antonio Eleuterio Ubilla
2. 1. First half
   2. -5'
      URU
      Yellow card
      F. Medina
   3. 20'
      URU
      GOOOAL!M. AffonsoAssist: B. Hernandez
   4. 39'
      URU
      Yellow card
      L. Sanseviero
   5. 45'
      URU
      Yellow card
      M. Brasil
   6. 45'
      URU
      Yellow card
      L. Sosa
   7. 45'
      URU
      GOOOAL!M. AffonsoAssist: F. Medina
3. 1. Second half
   2. 46'
      URU
      Substitution
      ▲S. Núñez▼J. Fernández
   3. 46'
      URU
      Substitution
      ▲E. Cardozo▼I. Pintos
   4. 49'
      URU
      GOOOAL!E. CardozoAssist: S. Nunez
   5. 59'
      URU
      Substitution
      ▲L. Otormín▼M. Affonso
   6. 60'
      URU
      Substitution
      ▲E. Femia▼R. Rabino
   7. 60'
      URU
      Substitution
      ▲F. Peraza▼F. Rossi
   8. 63'
      URU
      Substitution
      ▲M. Peralta▼?
   9. 67'
      URU
      Substitution
      ▲M. Añasco▼F. Medina
   10. 67'
       URU
       Substitution
       ▲J. Contrera▼B. Hernandez
   11. 71'
       URU
       Substitution
       ▲J. Millán▼L. Sosa
   12. 84'
       URU
       VAR review
       Sebastián Fernández
   13. 86'
       URU
       GOOOAL!Sebastián FernándezPenalty
   14. 89'
       URU
       Substitution
       ▲A. Di Pippa▼M. Brasil
   15. 90+2'
       URU
       Yellow card
       M. Argüello
   16. 90+4'
       URU
       Yellow card
       S. Romero
   17. 90+10'
       URU
       Red card
       Emiliano Velazquez
   18. 90+10'
       URU
       VAR review
       Emiliano Velazquez