Cerro Largo and Defensa y Justicia drew 0-0. Defensa y Justicia controlled the ball — 65% possession — but had nothing to show for it. Best on the pitch was A. Di Pippa, rated 7.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2025
   URU —·4-3-3 ARG
   Coach: — · Mariano Andrés SosoReferee: Mendez Chavez, Ivo Nigel, Bolivia📍 Estadio Centenario
2. 1. First half
   2. 12'
      ARG
      Yellow card
      Damián Pérez
3. 1. Second half
   2. 46'
      URU
      Substitution
      ▲L. Correa▼N. Bertochi
   3. 46'
      ARG
      Substitution
      ▲M. Ramirez▼G. Togni
   4. 66'
      ARG
      Substitution
      ▲A. Molinas▼B. Schamine
   5. 68'
      URU
      Substitution
      ▲M. Affonso▼F. Peraza
   6. 68'
      URU
      Substitution
      ▲F. Rossi▼L. Otormín
   7. 68'
      URU
      Substitution
      ▲M. Añasco▼M. Mir
   8. 80'
      URU
      Substitution
      ▲A. Pérez▼J. Contrera
   9. 82'
      URU
      Yellow card
      A. Pérez
   10. 86'
       ARG
       Substitution
       ▲A. Osorio▼J. B. Miritello
   11. 86'
       ARG
       Substitution
       ▲Alexis Soto▼Damián Pérez
   12. 86'
       ARG
       Substitution
       ▲N. Palavecino▼F. Gonzalez
   13. 88'
       ARG
       Yellow card
       E. Cannavo