Boston River beat Nacional Potosí 2-1. The winner had to work for it: 2 from 15 shots. Nacional Potosí played with ten from minute 50. Best on the pitch was F. Martínez, rated 7.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2025
   URU —·4-4-2 BOL
   Coach: — · Leonardo EguezReferee: Anderson Daronco, Brazil📍 Estadio Centenario
2. 1. First half
   2. 21'
      BOL
      GOOOAL!A. Torrico
   3. 35'
      URU
      VAR review
      J. Acosta
   4. 38'
      BOL
      Yellow card
      D. Palacio
   5. 45'
      URU
      Yellow card
      J. Gutierrez
3. 1. Second half
   2. 46'
      URU
      Substitution
      ▲A. Anello▼J. Gutierrez
   3. 50'
      BOL
      Yellow card
      D. Palacio
   4. 50'
      BOL
      Red card
      D. Palacio
   5. 57'
      URU
      GOOOAL!A. AlbarracinAssist: A. Amado
   6. 69'
      URU
      Substitution
      ▲G. Viera▼M. Vera
   7. 69'
      URU
      Substitution
      ▲A. González▼B. Barcia
   8. 70'
      URU
      GOOOAL!F. Martínez
   9. 75'
      BOL
      Substitution
      ▲J. Rojas▼Pedro Azogue
   10. 78'
       URU
       Substitution
       ▲Gastón Pérez▼A. Albarracin
   11. 85'
       BOL
       Substitution
       ▲D. Diellos▼M. Prost
   12. 85'
       BOL
       Substitution
       ▲C. Preciado▼L. Pavia
   13. 89'
       URU
       Substitution
       ▲F. Chiappini▼F. Noguera
   14. 90+1'
       URU
       Yellow card
       G. Viera
   15. 90+4'
       URU
       VAR review
       A. Anello