Independiente beat Club Guarani 1-0. The winner had to work for it: 1 from 34 shots. Best on the pitch was Felipe Loyola, rated 8.2.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2025
   ARG 4-2-3-1·4-4-2 PAR
   Coach: Julio César Vaccari · Víctor Eduardo Ceferino BernayReferee: Flavio Rodrigues De Souza, Brazil📍 Estadio Libertadores de América
2. 1. First half
   2. 35'
      ARG
      Yellow card
      Rodrigo Fernandez
   3. 43'
      ARG
      GOOOAL!D. Tarzia
3. 1. Second half
   2. 46'
      PAR
      Substitution
      ▲D. Fernandez▼R. Torales
   3. 61'
      PAR
      Substitution
      ▲V. Cespedes▼G. Vargas
   4. 61'
      PAR
      Substitution
      ▲William Mendieta▼N. Barrientos
   5. 65'
      PAR
      Substitution
      ▲I. Ramirez▼W. Ibarrola
   6. 66'
      ARG
      Substitution
      ▲S. Hidalgo▼M. Gimenez
   7. 66'
      ARG
      Substitution
      ▲Lautaro Millán▼S. Montiel
   8. 68'
      PAR
      Yellow card
      A. Manzur
   9. 74'
      ARG
      Substitution
      ▲P. Galdames▼Leandro Cabral
   10. 76'
       PAR
       Substitution
       ▲B. Piñatares▼A. Maíz
   11. 80'
       PAR
       Yellow card
       A. J. Benitez Cabrera
   12. 82'
       ARG
       Yellow card
       A. Angulo
   13. 89'
       ARG
       Substitution
       ▲S. Salle▼D. Tarzia
   14. 90+5'
       PAR
       Yellow card
       M. López