Cerro Largo beat Defensa y Justicia 1-2. Defensa y Justicia controlled the ball — 69% possession — but had nothing to show for it. Best on the pitch was A. Assis, rated 7.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2025
   ARG 4-3-3·— URU
   Coach: Mariano Andrés Soso · —Referee: Yender Herrera, Venezuela📍 Estadio Norberto Tomaghello
2. 1. First half
   2. 25'
      URU
      Yellow card
      M. Gianoli
   3. 33'
      ARG
      Yellow card
      K. Gutierrez
   4. 42'
      ARG
      Yellow card
      A. Osorio
   5. 45'
      URU
      GOOOAL!A. AssisAssist: M. Affonso
3. 1. Second half
   2. 52'
      URU
      GOOOAL!L. OtormínAssist: M. Affonso
   3. 54'
      URU
      Substitution
      ▲M. Añasco▼B. Hernandez
   4. 56'
      ARG
      Substitution
      ▲F. Gonzalez▼U. La Roza
   5. 56'
      ARG
      Substitution
      ▲D. Barbona▼R. Delgado
   6. 57'
      ARG
      Substitution
      ▲J. B. Miritello▼V. Larralde
   7. 59'
      ARG
      Yellow card
      Alexis Soto
   8. 67'
      ARG
      Substitution
      ▲A. Molinas▼L. Gonzalez
   9. 68'
      ARG
      GOOOAL!D. BarbonaAssist: F. Gonzalez
   10. 69'
       URU
       Substitution
       ▲A. Pérez▼L. Otormín
   11. 82'
       URU
       Substitution
       ▲F. Peraza▼M. Affonso
   12. 82'
       URU
       Substitution
       ▲M. Piriz▼A. García
   13. 82'
       URU
       Substitution
       ▲F. Parada▼N. Bertochi
   14. 84'
       ARG
       Substitution
       ▲M. Miranda▼T. Rubio
   15. 90+4'
       URU
       Yellow card
       M. Añasco