Independiente and Universidad de Chile drew 1-1. Independiente controlled the ball — 66% possession — but had nothing to show for it. Best on the pitch was M. G. Guerrero Pena, rated 7.3.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2025
   ARG 4-2-3-1·3-4-2-1 CHI
   Coach: Julio César Vaccari · Gustavo ÁlvarezReferee: Gustavo Tejera📍 Estadio Libertadores de América
2. 1. First half
   2. 11'
      CHI
      GOOOAL!L. AssadiAssist: L. Di Yorio
   3. 27'
      ARG
      GOOOAL!S. MontielAssist: G. Avalos
3. 1. Second half
   2. 46'
      ARG
      Substitution
      ▲Cristopher Toselli▼G. Castellon
   3. 46'
      ARG
      Substitution
      ▲F. Salomoni▼Matías Sepúlveda