Jorge Wilstermann beat Santa Fe 3-2. Renán López scored 2 goals.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 1961
   Referee: Juan Carlos Robles📍 Félix CaprilesAttendance: 35,000
2. 1. First half
   2. 8'
      BOL
      GOOOAL!RLRenán López
   3. 13'
      COL
      GOOOAL!OPOsvaldo Panzutto
   4. 17'
      BOL
      GOOOAL!CSCésar Sánchez
3. 1. Second half
   2. 76'
      BOL
      GOOOAL!RLRenán López
   3. 86'
      COL
      GOOOAL!RCRoberto Castro