Club Nacional beat Colo Colo 2-4. José Francisco Sanfilippo scored 2 goals.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 1964
   Referee: Jim Finney📍 NacionalAttendance: 41,280
2. 1. First half
   2. 6'
      URU
      GOOOAL!JSJosé Francisco Sanfilippo
   3. 44'
      URU
      GOOOAL!RLRafael Leites
3. 1. Second half
   2. 62'
      CHI
      Own goalEBEdgar Baeza
   3. 72'
      URU
      GOOOAL!JSJosé Francisco Sanfilippo
   4. 77'
      CHI
      GOOOAL!LÁLuis Álvarez
   5. 86'
      URU
      GOOOAL!VDVladas Douksas