Penarol beat Santos 3-2. Héctor Silva scored 2 goals.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 1965
   Referee: Luis Ventre📍 CentenarioAttendance: 67,130
2. 1. First half
   2. 8'
      URU
      GOOOAL!HSHéctor Silva
   3. 22'
      BRA
      GOOOAL!PEPepe
3. 1. Second half
   2. 57'
      BRA
      GOOOAL!COCoutinho
   3. 76'
      URU
      GOOOAL!JSJose F. SasiaPenalty
   4. 88'
      URU
      GOOOAL!HSHéctor Silva