Independiente beat Penarol 4-1.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 1965
   Referee: Arturo Yamasaki📍 NacionalAttendance: 40,000
2. 1. First half
   2. 9'
      ARG
      Own goalCPCarlos Pérez
   3. 27'
      ARG
      GOOOAL!RBRaul E. Bernao
   4. 33'
      ARG
      GOOOAL!RARoque Alberto Avallay
   5. 44'
      URU
      GOOOAL!JJJuan Joya
3. 1. Second half
   2. 81'
      ARG
      GOOOAL!OMOsvaldo Mura