Club Nacional beat U. Catolica 3-2. Orlando Virgili scored 2 goals.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 1966
   Referee: Roberto Goicoechea📍 CentenarioAttendance: 18,481
2. 1. First half
   2. 34'
      URU
      GOOOAL!JOJorge Oyarbide
   3. 38'
      CHI
      GOOOAL!JIJuan Inostroza
3. 1. Second half
   2. 48'
      URU
      GOOOAL!OVOrlando Virgili
   3. 74'
      CHI
      GOOOAL!ATArmando Tobar
   4. 89'
      URU
      GOOOAL!OVOrlando Virgili