Independiente beat Santa Fe 2-4. Agustin Balbuena scored 2 goals.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 1972
   Referee: Favilli Neto📍 El CampínAttendance: 35,000
2. 1. First half
   2. 19'
      ARG
      GOOOAL!ABAgustin Balbuena
   3. 43'
      ARG
      GOOOAL!ASAlejandro Semenewicz
   4. 45'
      COL
      GOOOAL!VCVictor Campaz
3. 1. Second half
   2. 54'
      ARG
      GOOOAL!ABAgustin Balbuena
   3. 73'
      ARG
      GOOOAL!DMDante Mircoli
   4. 87'
      COL
      GOOOAL!JCJosé Luis Cruz