Club Nacional beat Oriente Petrolero 1-3. Eduardo de la Peña scored 2 goals.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 1980
   Referee: Edison Pérez Núñez📍 Ramón Aguilera CostasAttendance: 25,000
2. 1. First half
   2. 37'
      BOL
      GOOOAL!CHCarlos Huguenet
   3. 45'
      URU
      GOOOAL!EPEduardo de la Peña
3. 1. Second half
   2. 60'
      URU
      GOOOAL!EPEduardo de la Peña
   3. 84'
      URU
      GOOOAL!DMDenis MilarPenalty