Deportivo Cali beat Junior 4-1. Alberto Benítez scored 2 goals.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 1981
   Referee: Sergio Leiblinger📍 Pascual GuerreroAttendance: 35,000
2. 1. First half
   2. 13'
      COL
      GOOOAL!EÁErnesto Álvarez
   3. 29'
      COL
      GOOOAL!ABAlberto Benítez
   4. 33'
      COL
      GOOOAL!JTJuan M. Tutino
3. 1. Second half
   2. 47'
      COL
      GOOOAL!RARafael Agudelo
   3. 53'
      COL
      GOOOAL!ABAlberto Benítez