Cobreloa beat Penarol 4-2. Víctor Merello scored 2 goals.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 1981
   Referee: Alirio Blanquiceth📍 Zorros del DesiertoAttendance: 9,996
2. 1. First half
   2. 1'
      CHI
      GOOOAL!RGRubén Gómez
   3. 30'
      CHI
      GOOOAL!VMVíctor Merello
3. 1. Second half
   2. 68'
      CHI
      GOOOAL!VMVíctor MerelloPenalty
   3. 70'
      URU
      GOOOAL!RPRubén PazPenalty
   4. 79'
      CHI
      GOOOAL!ÓMÓscar Muñoz
   5. 88'
      URU
      GOOOAL!EVErnesto Vargas