Fluminense beat Cerro Porteno 1-0. Cerro Porteno controlled the ball — 62% possession — but had nothing to show for it. Best on the pitch was Fred, rated 7.3.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   BRA 4-2-3-1·4-4-2 PAR
   Coach: Roger Machado · F. ArceReferee: W. Roldán📍 Estadio Jornalista Mário Filho
2. 1. First half
   2. 17'
      PAR
      Yellow card
      A. Espinola
   3. 24'
      BRA
      GOOOAL!FredPenalty
   4. 26'
      BRA
      Yellow card
      Luiz Henrique
   5. 26'
      PAR
      Yellow card
      C. Aquino
3. 1. Second half
   2. 56'
      PAR
      Yellow card
      J. Patiño
   3. 59'
      PAR
      Substitution
      ▲A. Rodríguez▼P. Adorno
   4. 63'
      BRA
      Yellow card
      Samuel Xavier
   5. 64'
      PAR
      Substitution
      ▲R. Morales▼C. Aquino
   6. 65'
      PAR
      Substitution
      ▲Adrián Martínez▼Federico Carrizo
   7. 68'
      BRA
      Yellow card
      Gabriel Teixeira
   8. 69'
      BRA
      Substitution
      ▲Kayky▼Luiz Henrique
   9. 72'
      BRA
      Substitution
      ▲Lucca▼Gabriel Teixeira
   10. 76'
       PAR
       Substitution
       ▲L. Vargas▼M. Boselli
   11. 77'
       PAR
       Yellow card
       M. Villasanti
   12. 80'
       BRA
       Substitution
       ▲Abel Hernández▼Fred
   13. 80'
       BRA
       Substitution
       ▲Andre▼Martinelli
   14. 81'
       BRA
       Substitution
       ▲Ganso▼Nenê
   15. 88'
       PAR
       Yellow card
       Adrián Martínez
   16. 89'
       BRA
       Yellow card
       Ganso