Deportivo Cali and Deportes Tolima drew 0-0. Deportivo Cali controlled the ball — 68% possession — but had nothing to show for it. Best on the pitch was J. Campaz, rated 7.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   COL 3-3-1-3·3-4-2-1 COL
   Coach: A. Arias · H. TorresReferee: C. Ortega📍 Estadio Deportivo Cali
2. 1. First half
   2. 3'
      COL
      Yellow card
      A. Balanta
   3. 12'
      COL
      Yellow card
      Jhon Narvaez
3. 1. Second half
   2. 46'
      COL
      Substitution
      ▲J. Ramírez▼A. Balanta
   3. 46'
      COL
      Substitution
      ▲Gastón Rodríguez▼J. Arce
   4. 46'
      COL
      Substitution
      ▲J. Vásquez▼J. Ramos
   5. 49'
      COL
      Yellow card
      J. Valencia
   6. 63'
      COL
      Yellow card
      Nilson Castrillon
   7. 63'
      COL
      Substitution
      ▲F. Torres▼Yeison Tolosa
   8. 78'
      COL
      Substitution
      ▲L. Miranda▼J. Ortiz
   9. 84'
      COL
      Substitution
      ▲G. Cabezas▼Juan Angulo
   10. 89'
       COL
       Substitution
       ▲G. Ramírez▼J. Campaz
   11. 90+3'
       COL
       Substitution
       ▲J. Hernández▼Omar Albornoz