Guabirá beat Nacional Potosí 1-2. Nacional Potosí controlled the ball — 72% possession — but had nothing to show for it. The winner had to work for it: 2 from 14 shots. Best on the pitch was K. Mina, rated 7.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   BOL 4-3-3·4-4-2 BOL
   Coach: A. Peña · V. AndradaReferee: G. Vargas📍 Estadio Victor Agustín Ugarte
2. 1. First half
   2. 14'
      BOL
      GOOOAL!K. MinaAssist: V. Galain
   3. 28'
      BOL
      Yellow card
      Alexis Hinestroza
   4. 45'
      BOL
      Yellow card
      Jefferson Ibáñez
3. 1. Second half
   2. 46'
      BOL
      Substitution
      ▲R. Cuellar Orti▼J. Rioja
   3. 46'
      BOL
      Substitution
      ▲Diego Navarro▼Rodrigo Vargas
   4. 46'
      BOL
      Substitution
      ▲Edenilson▼O. Añez
   5. 51'
      BOL
      Substitution
      ▲W. Álvarez▼K. Mina
   6. 61'
      BOL
      Substitution
      ▲D. Hoyos▼F. Domínguez
   7. 65'
      BOL
      Substitution
      ▲M. Barbery▼P. Jiménez
   8. 65'
      BOL
      Substitution
      ▲L. Guaqui▼S. Gularte
   9. 69'
      BOL
      GOOOAL!R. Cuellar OrtiAssist: L. Guaqui
   10. 71'
       BOL
       Substitution
       ▲N. Amarilla▼Luis Hurtado
   11. 71'
       BOL
       Substitution
       ▲Bruno Pascua▼J. Vogliotti
   12. 73'
       BOL
       Yellow card
       Edenilson
   13. 82'
       BOL
       GOOOAL!W. ÁlvarezAssist: F. Supayabe
   14. 90'
       BOL
       Yellow card
       L. Torrico