Penarol beat Cerro Largo 4-1. Agustín Álvarez Martínez scored 2 goals. Best on the pitch was Agustín Álvarez Martínez, rated 8.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   URU 4-4-2·4-1-4-1 URU
   Coach: M. Larriera · L. NúñezReferee: A. Cunha📍 Estadio Campeón del Siglo
2. 1. First half
   2. 3'
      URU
      Yellow card
      M. Estol
   3. 4'
      URU
      GOOOAL!Agustín Álvarez MartínezAssist: F. Formiliano
   4. 18'
      URU
      Substitution
      ▲R. Abascal▼F. Formiliano
   5. 19'
      URU
      Yellow card
      R. Abascal
   6. 20'
      URU
      GOOOAL!M. Estol
   7. 30'
      URU
      GOOOAL!F. TorresAssist: Agustín Álvarez Martínez
   8. 43'
      URU
      GOOOAL!Agustín Álvarez MartínezAssist: J. Piquerez
3. 1. Second half
   2. 46'
      URU
      Substitution
      ▲E. Etcheverry▼Leandro Onetto
   3. 46'
      URU
      Substitution
      ▲H. Pereira▼F. Rodríguez
   4. 51'
      URU
      Substitution
      ▲R. Dorrego▼G. Machado
   5. 51'
      URU
      Substitution
      ▲F. Núñez▼F. García
   6. 54'
      URU
      Yellow card
      E. Etcheverry
   7. 60'
      URU
      Own goalR. Ferreira
   8. 63'
      URU
      Yellow card
      E. Beltran
   9. 64'
      URU
      Yellow card
      M. Brasil
   10. 74'
       URU
       Yellow card
       G. Baez Corradi
   11. 75'
       URU
       Substitution
       ▲C. Núñez▼M. Estol
   12. 78'
       URU
       Substitution
       ▲Agustín Álvarez Wallace▼Walter Gargano
   13. 87'
       URU
       Yellow card
       C. Núñez