Atletico Paranaense beat America de Cali 4-1. America de Cali played with ten from minute 55. Vitinho scored 2 goals. Best on the pitch was Nikão, rated 8.5.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   BRA 4-2-3-1·5-3-2 COL
   Coach: António Oliveira · J. OsorioReferee: D. Herrera📍 Arena da Baixada
2. 1. First half
   2. 26'
      BRA
      GOOOAL!VitinhoAssist: Nikão
   3. 30'
      COL
      Yellow card
      K. Andrade
   4. 45'
      COL
      Yellow card
      H. Quiñónes
3. 1. Second half
   2. 46'
      COL
      Substitution
      ▲E. Batalla▼J. Malagón
   3. 46'
      COL
      Substitution
      ▲J. Rodríguez▼C. Cortés
   4. 55'
      COL
      Yellow card
      K. Andrade
   5. 55'
      COL
      Red card
      K. Andrade
   6. 60'
      BRA
      Yellow card
      Thiago Heleno
   7. 66'
      COL
      VAR review
      R. Urena
   8. 70'
      COL
      GOOOAL!Adrian RamosPenalty
   9. 71'
      BRA
      GOOOAL!VitinhoAssist: Nikão
   10. 77'
       COL
       Yellow card
       J. Graterol
   11. 79'
       BRA
       GOOOAL!NikãoPenalty
   12. 82'
       BRA
       Substitution
       ▲Jádson▼D. Terans
   13. 82'
       BRA
       Substitution
       ▲Renato Kayser▼Matheus Babi
   14. 88'
       BRA
       Substitution
       ▲Jaderson▼Vitinho
   15. 89'
       BRA
       Substitution
       ▲Fernando Canesin▼Christian
   16. 90+1'
       BRA
       Substitution
       ▲Luan Patrick▼Léo Cittadini
   17. 90+7'
       BRA
       GOOOAL!Fernando CanesinAssist: Jádson