Club Nacional beat Penarol 0-1. Club Nacional played with ten from minute -5. Best on the pitch was G. Corujo, rated 8.5.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   URU 4-4-1-1·4-1-4-1 URU
   Coach: M. Larriera · A. CapuccioReferee: Anderson Daronco📍 Estadio Campeón del Siglo
2. 1. First half
   2. -5'
      URU
      Yellow card
      J. Acosta
   3. -5'
      URU
      Red card
      M. Cantera
   4. 20'
      URU
      Yellow card
      M. Cantera
3. 1. Second half
   2. 62'
      URU
      Yellow card
      Leandro Fernandez
   3. 67'
      URU
      Substitution
      ▲T. Vecino▼Leandro Fernandez
   4. 67'
      URU
      Substitution
      ▲A. Trezza▼M. Cantera
   5. 81'
      URU
      Substitution
      ▲Damian Musto▼Walter Gargano
   6. 83'
      URU
      Yellow card
      G. González
   7. 83'
      URU
      Yellow card
      A. Trezza
   8. 90'
      URU
      Red card
      Damian Musto
   9. 90'
      URU
      Red card
      F. Carballo
   10. 90+1'
       URU
       Substitution
       ▲A. Nahuelpán▼Agustín Álvarez Martínez
   11. 90+2'
       URU
       Substitution
       ▲Valentín Rodríguez▼F. Torres
   12. 90+11'
       URU
       Substitution
       ▲Carlos Rodríguez▼A. Canobbio
   13. 90+11'
       URU
       GOOOAL!G. CorujoAssist: B. Ocampo