Libertad Asuncion beat Santos 1-0. Santos controlled the ball — 63% possession — but had nothing to show for it. The winner had to work for it: 1 from 18 shots. Santos played with ten from minute 90. Best on the pitch was Wagner, rated 7.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   PAR 4-5-1·4-4-2 BRA
   Coach: D. Garnero · Fernando DinizReferee: A. Herrera📍 Estadio Defensores del Chaco
2. 1. First half
   2. 14'
      PAR
      GOOOAL!S. Ferreira
   3. 23'
      PAR
      Yellow card
      Leonel Vangioni
   4. 37'
      PAR
      Yellow card
      Alex Terra
3. 1. Second half
   2. 46'
      BRA
      Substitution
      ▲Marcos Leonardo▼Gabriel Pirani
   3. 57'
      BRA
      Substitution
      ▲Moraes▼Felipe Jonatan
   4. 66'
      BRA
      Yellow card
      Marcos Leonardo
   5. 68'
      BRA
      Yellow card
      Luiz Felipe
   6. 71'
      BRA
      Substitution
      ▲Ângelo▼Carlos Sánchez
   7. 71'
      BRA
      Substitution
      ▲Bruninho▼Jean Mota
   8. 73'
      BRA
      Yellow card
      Marcos Guilherme
   9. 82'
      PAR
      Substitution
      ▲Ivan Franco▼Héctor Villalba
   10. 83'
       PAR
       Yellow card
       Daniel Bocanegra
   11. 86'
       PAR
       Substitution
       ▲M. Espinoza▼Leonel Vangioni
   12. 89'
       BRA
       Substitution
       ▲Raniel▼Luiz Felipe
   13. 90'
       PAR
       Yellow card
       H. Martínez
   14. 90'
       BRA
       Yellow card
       João Paulo
   15. 90'
       BRA
       Red card
       Marcos Leonardo
   16. 90+2'
       PAR
       Substitution
       ▲Óscar Cardozo▼S. Ferreira