Atletico Paranaense beat Penarol 2-0. Best on the pitch was Nikão, rated 8.2.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   BRA 3-4-2-1·4-1-4-1 URU
   Coach: Alberto Valentim · M. LarrieraReferee: J. Valenzuela📍 Arena da Baixada
2. 1. First half
   2. 24'
      BRA
      GOOOAL!NikãoAssist: D. Terans
   3. 36'
      URU
      Yellow card
      Agustín Álvarez Martínez
   4. 45'
      BRA
      Yellow card
      Zé Ivaldo
   5. 45'
      URU
      Yellow card
      J. Ramos
3. 1. Second half
   2. 57'
      URU
      Substitution
      ▲A. Nahuelpán▼Pablo Ceppelini
   3. 57'
      URU
      Substitution
      ▲Valentín Rodríguez▼J. Ramos
   4. 59'
      BRA
      Substitution
      ▲Renato Kayser▼Guilherme Bissoli
   5. 66'
      BRA
      Substitution
      ▲Léo Cittadini▼Erick
   6. 66'
      BRA
      Substitution
      ▲Pedro Rocha▼D. Terans
   7. 70'
      URU
      Yellow card
      A. Canobbio
   8. 71'
      URU
      Substitution
      ▲I. Laquintana▼F. Torres
   9. 79'
      URU
      Substitution
      ▲M. Alonso▼A. Canobbio
   10. 79'
       URU
       Substitution
       ▲Nicolás Gaitán▼Agustín Álvarez Martínez
   11. 80'
       BRA
       GOOOAL!Pedro RochaAssist: Nikão
   12. 86'
       BRA
       Substitution
       ▲Lucas Fasson▼Richard
   13. 86'
       BRA
       Substitution
       ▲Nicolas▼Zé Ivaldo