America de Cali edged Independiente Medellin 2-1 after extra time. The winner had to work for it: 2 from 19 shots. Best on the pitch was Adrian Ramos, rated 8.3.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2022
   COL 4-1-4-1·4-4-2 COL
   Coach: J. Osorio · J. ComesañaReferee: A. Herrera📍 Estadio Olímpico Pascual Guerrero
2. 1. First half
   2. 9'
      COL
      GOOOAL!C. Sierra
   3. 24'
      COL
      GOOOAL!L. PonsAssist: A. Arregui
   4. 45+2'
      COL
      Yellow card
      Germán Gutiérrez
   5. 45+4'
      COL
      Yellow card
      A. Mosquera
   6. 45+5'
      COL
      Substitution
      ▲D. Cambindo▼L. Pons
3. 1. Second half
   2. 46'
      COL
      Substitution
      ▲J. Micolta▼E. Moreno
   3. 46'
      COL
      Substitution
      ▲E. Acevedo▼John García
   4. 56'
      COL
      Yellow card
      J. Segura
   5. 62'
      COL
      Substitution
      ▲A. Quintana▼D. Quiñónes
   6. 62'
      COL
      Substitution
      ▲Larry Angulo▼C. Sierra
   7. 63'
      COL
      Substitution
      ▲D. Hernández▼Iago Falqué
   8. 63'
      COL
      GOOOAL!Adrian RamosAssist: E. Mosquera
   9. 67'
      COL
      Substitution
      ▲Felipe Pardo▼Juan Guillermo Arboleda
   10. 67'
       COL
       Substitution
       ▲J. Hernández▼Vladimir Hernández
   11. 73'
       COL
       Substitution
       ▲J. Méndez▼J. Pineda
4. 1. Penalties
   2. 120+1'
      COL
      Shootout miss
      A. Quintana
   3. 120+2'
      COL
      GOOOAL!Andres CadavidPenalty shootout
   4. 120+3'
      COL
      Shootout miss
      D. Hernández
   5. 120+4'
      COL
      GOOOAL!A. ArreguiPenalty shootout
   6. 120+5'
      COL
      GOOOAL!Larry AnguloPenalty shootout
   7. 120+6'
      COL
      Shootout miss
      J. Hernández
   8. 120+7'
      COL
      Shootout miss
      Elvis Mosquera
   9. 120+8'
      COL
      GOOOAL!D. LoaizaPenalty shootout