Deportivo Tachira FC knocked Santos out on penalties 4-2, after a 1-1 draw. Santos played with ten from minute 45. Best on the pitch was C. Varela, rated 8.3.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2022
   BRA 4-2-3-1·4-2-3-1 VEN
   Coach: F. Bustos · Álex PallarésReferee: K. Ortega📍 Estádio Urbano Caldeira
2. 1. First half
   2. 6'
      VEN
      Yellow card
      Francisco Flores
   3. 24'
      VEN
      Yellow card
      M. Cova
   4. 27'
      VEN
      GOOOAL!A. Uribe
   5. 31'
      VEN
      VAR review
      A. Uribe
   6. 42'
      BRA
      Yellow card
      Marcos Leonardo
   7. 45+3'
      BRA
      Red card
      Rodrigo Fernandez
   8. 45+5'
      BRA
      Yellow card
      João Paulo
   9. 45+7'
      VEN
      Yellow card
      A. Uribe
3. 1. Second half
   2. 46'
      BRA
      Substitution
      ▲Rwan Cruz▼Kaiky
   3. 46'
      BRA
      Substitution
      ▲Sandry▼Bruno Oliveira
   4. 59'
      VEN
      Yellow card
      Y. Chacón
   5. 60'
      BRA
      Substitution
      ▲Lucas Barbosa▼Ângelo
   6. 63'
      VEN
      Substitution
      ▲Richard Figueroa▼Robert Hernandez
   7. 63'
      VEN
      Substitution
      ▲R. Simisterra▼A. Uribe
   8. 68'
      BRA
      Substitution
      ▲Carlos Sánchez▼Vinicius Zanocelo
   9. 69'
      BRA
      GOOOAL!Marcos LeonardoAssist: C. Sánchez
   10. 71'
       BRA
       Yellow card
       Lucas Pires
   11. 76'
       VEN
       Substitution
       ▲R. Arace▼Y. Chacón
   12. 84'
       VEN
       Yellow card
       A. Ariano
   13. 90+2'
       BRA
       Substitution
       ▲Ricardo Goulart▼Lucas Pires
   14. 90+4'
       VEN
       Substitution
       ▲M. Fernández▼Richard Figueroa
   15. 90+5'
       VEN
       Substitution
       ▲Edder Farias▼R. Garcés
4. 1. Penalties
   2. 120+1'
      BRA
      Shootout miss
      Ricardo Goulart
   3. 120+2'
      VEN
      GOOOAL!Edder FariasPenalty shootout
   4. 120+3'
      BRA
      GOOOAL!SandryPenalty shootout
   5. 120+4'
      VEN
      GOOOAL!R. SimisterraPenalty shootout
   6. 120+5'
      BRA
      GOOOAL!Carlos SánchezPenalty shootout
   7. 120+6'
      VEN
      GOOOAL!R. AracePenalty shootout
   8. 120+7'
      BRA
      Shootout miss
      Lucas Barbosa
   9. 120+8'
      VEN
      GOOOAL!M. FernándezPenalty shootout