FBC Melgar beat Deportivo Cali 2-1. The winner had to work for it: 2 from 20 shots. Bernardo Cuesta scored 2 goals. Best on the pitch was Bernardo Cuesta, rated 8.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2022
   PER 4-2-3-1·— COL
   Coach: N. Lorenzo · —Referee: F. Tello📍 Estadio de la Universidad Nacional San Agustín
2. 1. First half
   2. 37'
      COL
      Yellow card
      Teófilo Gutiérrez
3. 1. Second half
   2. 51'
      PER
      Yellow card
      A. Deneumostier
   3. 55'
      PER
      VAR review
      W. Tandazo
   4. 58'
      COL
      Yellow card
      K. Velasco
   5. 58'
      PER
      GOOOAL!Bernardo CuestaPenalty
   6. 60'
      COL
      Substitution
      ▲H. Mosquera▼Christian Mafla
   7. 67'
      PER
      Substitution
      ▲J. Archimbaud▼M. Pérez Guedes
   8. 67'
      PER
      Substitution
      ▲C. Bordacahar▼K. Quevedo
   9. 73'
      PER
      GOOOAL!Bernardo CuestaAssist: L. Iberico
   10. 78'
       COL
       Substitution
       ▲O. Segura▼Y. González
   11. 78'
       COL
       Substitution
       ▲J. Mina▼A. Gutiérrez
   12. 89'
       PER
       Yellow card
       P. Reyna
   13. 90+1'
       PER
       Substitution
       ▲K. G. Cabrera Nakamura▼L. Iberico
   14. 90+1'
       PER
       Substitution
       ▲Joel Sánchez▼A. Arias
   15. 90+1'
       COL
       Substitution
       ▲Y. Congo▼Carlos Robles
   16. 90+7'
       COL
       GOOOAL!H. MosqueraAssist: T. Gutiérrez